IIT Mandi researchers decode how excess sugar intake causes fatty liver disease

IIT Mandi researchers decode how excess sugar intake causes fatty liver disease

MANDI [Maha Media]: A team of researchers from the Indian Institute of Technology (IIT), Mandi has unravelled the molecular mechanism by which excess sugar consumption causes fatty liver disease. According to the team, the research will prompt the public to reduce sugar intake to stop Non-Alcoholic Fatty Liver Disease (NAFLD) in its early stages.

The research, which comes at a time when the government has included NAFLD in the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS), has been published in the Journal of Biological Chemistry. NAFLD is a medical condition in which excess fat deposits in the liver. The disease starts silently, with no overt symptoms for as long as two decades. If left untreated, the excess fat can irritate the liver cells, resulting in scarring of the liver (cirrhosis). In advanced cases, it can also lead to liver cancer. "One of the causes of NAFLD is the overconsumption of sugar -- both table sugar (sucrose) and other forms of carbohydrates. The consumption of excess sugar and carbohydrates causes the liver to convert them into fat through a process called hepatic De Novo Lipogenesis or DNL, which leads to fat accumulation in the liver," said Prosenjit Mondal, associate professor, School of Basic Sciences, IIT Mandi.
 

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